The IX53 has been designed from the ground up to be the finest microscope available for routine inverted microscopic analysis. The combination of excellent optical performance and mechanical quality results in a microscope system of outstanding value and comfort for regular use.

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Expandable to Meet Growing Research Needs

The IX53 system is the ideal solution for routine analysis. End-users can improve research efficiency by recording cell dynamics across a wide area. Reliability can also be enhanced through accurate position and light reproducibility.

IX53: One-deck System

An outstanding, cost-effective microscope for brightfield and fluorescence applications.

Reliable, Clear and High-Resolution Images

Olympus UIS2 infinity-corrected optics ensure high optical transmittance with a broad range of objectives. UIS2 optics feature wide chromatic correction and enable high resolution, high S/N primary images regardless of the observation method.

Excellent Image Quality

Apochromatic Objectives Enable High-Resolution Phase Contrast and Fluorescence Observation

Phase contrast apochromatic objectives (UPLSAPO100XOPH, PLAPON60XOPH) enable high-precision imaging free from image shift, even during simultaneous phase contrast and fluorescence observation. This eliminates the need to change objectives when switching observation methods.


HeLa cell expressing mCherry-actin
Image data courtesy of: Tomonobu Watanabe, Ph.D. Laboratory for Comprehensive Bioimaging, RIKEN Quantitative Biology Center


UPLSAPO100×OPH, PLAPON60×OPH

Special Objective Available for iPS/ES and Floating Cell Observation

This high-NA phase contrast objective (UCPLFLN20XPH) is especially suited for observation using plastic dishes. It enables high-resolution observation of the cell proliferation process and delivers improved contrast across a wide area.

Phase contrast observation
Fluorescence observation
UCPLFLN20XPH
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High S/N Fluorescence Mirror Units for Efficient Signal Detection

All fluorescence mirror units feature filters treated with a specially-developed coating that minimizes noise by absorbing more than 99 % of stray light. The outstanding performance and high transmittance of the mirror units ensure efficient fluorescence signal detection.

High S/N Fluorescence Mirror Units for Efficient Signal Detection

Left: Image Captured with a Conventional FL Mirror Unit / Right: Images Captured with New FL Mirror Units

Accuracy and Repeatability

Smooth Tracking at High Magnification

The IX3-SVR manual stage features a smooth positioning system that enables cells to be easily tracked, even at high magnifications. 

  • Observation limit settings immobilize the stage and help maintain its position, including during reagent applications, even if the stage is inadvertently touched.
  • Using the stage's fixing plate and positioning screws, you can remove a 35 mm dish from the stage, transfer it to an incubator, and return it to its exact previous position.

Easy Köehler Illumination

The condenser can be moved and easily reset to Köhler illumination using the conveniently located condenser lock and control knobs. 

Optional Fluorescence illuminator

Long Life 130W Mercury Lamp (U-HGLGPS)

The U-HGLGPS fluorescence light source delivers bright, even illumination and features a long life, 2,000-hour mercury burner (average lifetime). The unit is maintenance-free and does not require centering adjustment. A liquid light guide prevents heat transfer to samples, thus allowing extended observations to be carried out without concern.