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Complex Human Vascularized Tissue Models

Description: We have fabricated multicomponent, vascularized thick tissue constructs and organoids, which are useful in research, pharmaceutical, and autologous therapeutic applications, using robotic tissue fabrication and isolated microvessel technologies. We demonstrate, via advanced imaging and functional assays, that the integrated microvasculature of these tissue constructs and organoids imparts new functionality to the models.

Presenter: James B. Hoying, PhD, Chief Scientist, ASI Life Sciences

James B. Hoying

James (Jay) Hoying is a Partner and Chief Scientist with Advanced Solutions Life Sciences. He has more than 25 years of experience in basic and applied biological sciences with a focus on tissue biology and tissue vascularization. Previously, he was Professor and Chief of the Division of Cardiovascular Therapeutics at the Cardiovascular Innovation Institute (CII) where he developed a broad background in tissue fabrication, cell therapeutics, and translation of discoveries to industry and the clinic. Dr. Hoying is an inventor of the Angiomics™ microvessel technology and holds numerous patents related to vascularizing tissues and related cell-based therapies. Dr. Hoying received his BA and MS degrees in Biology and Molecular Biology from Case Western Reserve University and his PhD in Cardiovascular Physiology, with an emphasis on microcirculation, from the University of Arizona. Following this, Dr. Hoying served as a New Investigator in the National Institutes of Health’s Program of Excellence in Molecular Biology of the Heart and Lung (POEMB). He currently serves on the editorial staff of two national scientific journals and reviews for several other national and international journals. Dr. Hoying reviews individual and program grant proposals for the National Institutes of Health, the Veterans Affairs, the American Heart Association, and international funding agencies. Dr. Hoying is also a Fellow of the American Heart Association.

Complex Human Vascularized Tissue Models

We have fabricated multicomponent, vascularized thick tissue constructs and organoids, which are useful in research, pharmaceutical, and autologous therapeutic applications, using robotic tissue fabrication and isolated microvessel technologies. We demonstrate, via advanced imaging and functional assays, that the integrated microvasculature of these tissue constructs and organoids imparts new functionality to the models.

Presenter: James B. Hoying, PhD, Chief Scientist, ASI Life Sciences

James B. Hoying

James (Jay) Hoying is a Partner and Chief Scientist with Advanced Solutions Life Sciences. He has more than 25 years of experience in basic and applied biological sciences with a focus on tissue biology and tissue vascularization. Previously, he was Professor and Chief of the Division of Cardiovascular Therapeutics at the Cardiovascular Innovation Institute (CII) where he developed a broad background in tissue fabrication, cell therapeutics, and translation of discoveries to industry and the clinic. Dr. Hoying is an inventor of the Angiomics™ microvessel technology and holds numerous patents related to vascularizing tissues and related cell-based therapies. Dr. Hoying received his BA and MS degrees in Biology and Molecular Biology from Case Western Reserve University and his PhD in Cardiovascular Physiology, with an emphasis on microcirculation, from the University of Arizona. Following this, Dr. Hoying served as a New Investigator in the National Institutes of Health’s Program of Excellence in Molecular Biology of the Heart and Lung (POEMB). He currently serves on the editorial staff of two national scientific journals and reviews for several other national and international journals. Dr. Hoying reviews individual and program grant proposals for the National Institutes of Health, the Veterans Affairs, the American Heart Association, and international funding agencies. Dr. Hoying is also a Fellow of the American Heart Association.

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