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Human Skin Epidermoid Carcinoma Epithelial Cells (A-431)
The A-431 cell line, which was derived from an epidermoid carcinoma excised from the skin tissue of an 85-year-old female, is one of a succession of cell lines established from solid tumors by a research team led by D. J. Giard. The epithelial line is tumorigenic, forming rapidly growing subcutaneous tumors in immunosuppressed mice and colonies in soft agar. Also known as cutaneous squamous cell carcinoma, epidermoid carcinoma of the skin is a malignant tumor of epidermal keratinocytes, a condition that has increased in frequency considerably over the last century, perhaps due in part to the ongoing depletion of the protective ozone layer.
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