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Dr. Dong Gao
Dr. Dong Gao

Dr. Dong Gao

Principal Investigator

Dr. Dong Gao is the Principal Investigator of Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. His research interests mainly focus on t prostate adult stem cell and the establishment of patients-derived cancer organoid biobank. He has authored more than 40 papers including Cell, Nature Genetics, Cell Stem Cell et al.

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Prostate Cell Lineage Hierarchy and Plasticity

Prostate Cell Lineage Hierarchy and Plasticity

Experten
Dr. Dong Gao
Principal Investigator
Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Prostate cancer is one of the most common cancers worldwide and also the second leading cause of cancer-related death in males in Western countries. Although the majority of human primary prostate cancers have a luminal phenotype, both basal cells and luminal cells can serve as cellular origins of prostate cancer in model systems. However, the stem cell-like plasticity of defined prostate epithelial cells and the cellular origin of prostate cancer under physiological conditions have not been identified. Recently, prostate basal and luminal cell populations were both shown to be self-sustaining, and both cell types could initiate prostate cancer. However, the oncogenic transformation of basal cells requires basal to luminal cell transition. In addition, luminal cells were shown to have greater tendency to be the cells of origin for prostate cancer in some contexts.
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