Dr. Gowri Balachander
Dr. Gowri Balachander
Research Fellow, Translation Mechanobiology lab, National University of Singapore
Dr. Gowri Balachander is a Research Fellow at the Yong Loo Lin School of Medicine, National University of Singapore. She completed her PhD at the prestigious Indian Institute of Science, Bangalore, India where she worked on engineering 3D organotypic models for the study of breast cancer metastasis. At NUS, she currently works on morphogenetic models for human liver development and regeneration.
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Depth Matters: Transforming Biology for More Realistic and Meaningful Pursuits
Quarta, 28 Julho, 2021
Especialistas
Dr. Gowri Balachander
Research Fellow, Translation Mechanobiology lab, National University of Singapore
Improvements to in vitro three-dimensional (3D) models are making them increasingly better at mimicking in vivo-like cellular behavior. Every tissue presents a distinct microenvironment with a unique blend of biochemical and biophysical components that dictate cellular behavior. Recreation of critical features of tissues that nurtures recapitulation of in vivo-like cellular behavior is the essence of an effective 3D model. In this webinar, through specific examples of 3D models for tissue development and cancer, we will revisit the fundamental principles of designing 3D models that can effectively recapitulate critical features of the tissues in vitro and applications of such models in mechanistic studies and drug testing. Our work also highlights the importance of 3D imaging systems, such as laser scanning confocal microscopes, which are necessary for such work.