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Note d’application

Support Biopsy Efficiency with the Simplified Operation of the IX73 Inverted Microscope

The Challenge

With objectives of lowering the miscarriage rate and improving the implantation rate, preimplantation genetic testing (PGT) is rising in popularity worldwide; therefore, the number of embryo biopsies performed is increasing accordingly.

In an embryo biopsy, some cells are removed from the embryo under an inverted microscope using relief contrast observation. The appropriate contrast adjustment is required to determine the location to irradiate the laser and the suction the cells, but complex microscope operations can cause user fatigue.

Olympus’ Solution to Improve the Efficiency of the Biopsy Workflow

Olympus’ relief contrast enables observation of 3-dimensional oocytes in plastic dishes. Since the relief contrast imaging is unaffected by the polarizing effect of the plastic dish, you can clearly view the oocyte zona pellucida to check its condition.

In addition, the dedicated remote hand switch of the IX73 semi-motorized system makes it easy to achieve suitable contrast and magnification/condenser settings with the push of a button. Streamlining the microscope operation to a minimum enables users to concentrate on the delicate biopsy manipulations, which require careful attention. Since the motorized operation using the hand switch reduces user intervention above the stage, it also decreases the risk of accidentally touching the sample or needle of the injector.


Remote hand switch

画像提供元: Cooper Surgical, Inc.

Samples and images data are courtesy of Cooper Surgical Inc.

Summary of the IX73 Semi-Motorized System’s Advantages for Embryo Biopsies

The IX73 system’s remote hand switch simplifies and streamlines microscope operations, supporting reliable and efficient embryo biopsies. The improved microscope operation workflow helps you manage the increased embryo biopsy workload.

Comment by Dr. Watanabe

When performing an embryo biopsy using the IX73 semi-motorized system, I am impressed by the smooth control of the magnification and laser system with the dedicated hand switch. In the past, when changing the magnification, we had to touch the condenser and objective lens, which required careful operation. I, like many users, have experienced shaking the microscope by accidentally touching it too forcefully. The IX73 semi-motorized system enables you to perform these operations by lightly pressing a switch without touching the microscope, so you can focus more on the embryo biopsy itself.

This application note was prepared with the help of the following researcher:
Dr. Hideaki Watanabe
Sugiyama Clinic Shinjuku
Center for Reproductive Medicine and Implantation Research


IIX3-ICSI/IMSI inverted microscope

Produits utilisés pour cette application

Plateformes IICS/IMSI


Le système IX3-ICSI est conçu pour faciliter l’utilisation de l’injection intracytoplasmique de spermatozoïdes (IICS) dans le cadre du processus de fécondation in vitro (FIV). La méthode de contraste de relief d’Olympus permet l’observation d’ovocytes en 3D dans des boîtes de Petri en plastique pour vérifier l’état de la zone pellucide. Le système semi-motorisé IX3 est doté d’une commande manuelle dédiée à l’ICSI qui permet de changer instantanément la méthode d’observation et le grossissement d’une simple pression sur un bouton. Utilisez la méthode de polarisation pour observer le fuseau mitotique et sa position pour vérifier la maturité des ovocytes et éviter tout dommage pendant l’injection et la méthode de contraste interférentiel différentiel (CID) pour effectuer l’injection intracytoplasmiques de spermatozoïdes morphologiquement sélectionnés (IMSI).

  • Optimisé pour assurer une procédure d’ICSI plus fluide
  • Vérification aisée de l’état des ovocytes grâce à la visualisation des fuseaux mitotiques
  • Étapes d’ICSI simplifiées grâce au fonctionnement motorisé

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