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Support Biopsy Efficiency with the Simplified Operation of the IX73 Inverted Microscope

The Challenge

With objectives of lowering the miscarriage rate and improving the implantation rate, preimplantation genetic testing (PGT) is rising in popularity worldwide; therefore, the number of embryo biopsies performed is increasing accordingly.

In an embryo biopsy, some cells are removed from the embryo under an inverted microscope using relief contrast observation. The appropriate contrast adjustment is required to determine the location to irradiate the laser and the suction the cells, but complex microscope operations can cause user fatigue.

Olympus’ Solution to Improve the Efficiency of the Biopsy Workflow

Olympus’ relief contrast enables observation of 3-dimensional oocytes in plastic dishes. Since the relief contrast imaging is unaffected by the polarizing effect of the plastic dish, you can clearly view the oocyte zona pellucida to check its condition.

In addition, the dedicated remote hand switch of the IX73 semi-motorized system makes it easy to achieve suitable contrast and magnification/condenser settings with the push of a button. Streamlining the microscope operation to a minimum enables users to concentrate on the delicate biopsy manipulations, which require careful attention. Since the motorized operation using the hand switch reduces user intervention above the stage, it also decreases the risk of accidentally touching the sample or needle of the injector.


Remote hand switch

画像提供元: Cooper Surgical, Inc.

Samples and images data are courtesy of Cooper Surgical Inc.

Summary of the IX73 Semi-Motorized System’s Advantages for Embryo Biopsies

The IX73 system’s remote hand switch simplifies and streamlines microscope operations, supporting reliable and efficient embryo biopsies. The improved microscope operation workflow helps you manage the increased embryo biopsy workload.

Comment by Dr. Watanabe

When performing an embryo biopsy using the IX73 semi-motorized system, I am impressed by the smooth control of the magnification and laser system with the dedicated hand switch. In the past, when changing the magnification, we had to touch the condenser and objective lens, which required careful operation. I, like many users, have experienced shaking the microscope by accidentally touching it too forcefully. The IX73 semi-motorized system enables you to perform these operations by lightly pressing a switch without touching the microscope, so you can focus more on the embryo biopsy itself.

This application note was prepared with the help of the following researcher:
Dr. Hideaki Watanabe
Sugiyama Clinic Shinjuku
Center for Reproductive Medicine and Implantation Research


IIX3-ICSI/IMSI inverted microscope

이 애플리케이션에 사용되는 제품



IX3-ICSI 시스템은 체외 수정(IFV) 프로세스의 일부로서 세포질 내 정자 주입(ICSI)의 사용을 용이하게 하도록 설계되었습니다. Olympus의 릴리프 콘트라스트 방식은 플라스틱 접시에서 3D 난모세포를 관찰하여 투명대 상태를 확인할 수 있도록 지원합니다. IX3 반전동 시스템에는 버튼 터치만으로 관찰 방법과 배율을 즉시 변경할 수 있는 ICSI 전용 핸드 스위치가 있습니다. 편광 방법을 사용하여 스핀들 및 스핀들 위치를 관찰함으로써 난모세포 성숙도를 확인하고 주입 시 손상을 방지하며 미분 간섭 대비(DIC)를 통해 형태를 기준으로 선택된 정자의 세포질 내 주입(IMSI)을 수행할 수 있습니다.

  • 보다 원활한 ICSI 워크플로에 최적화
  • 스핀들 시각화를 통해 난자 상태를 쉽게 확인
  • 전동식 작동을 통해 ICSI 단계 간소화

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